José-Tomás (JT) Prieto

Director of AI Programs at Apheris

JT is the director of AI programs at Apheris, specializing in AI for healthcare and life sciences industries. He holds a PhD in economics with a focus on digital health and privacy. JT has led forward-deployed teams across several industries, including global health and healthcare, and worked for institutions such as the US Centers for Disease Control and Prevention and Palantir Technologies. He focuses on integrating responsible AI governance programs that meet evolving regulatory and organizational requirements.

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Articles by

José-Tomás (JT) Prieto

Co-Folding AI
Lead Optimization
AI Drug Discovery

Fine-tuning the OpenFold3 affinity head on a small JAK2 macrocycle dataset

We rebuilt the SandboxAQ affinity head inside ApherisFold and fine-tuned it on 49 JAK2 macrocycles. Architectural changes alone lifted Spearman ranking from 0.418 to 0.60; fine-tuning then pushed validation Pearson from 0.23 to 0.76, mostly by correcting how the model handled inactives.

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Federated Learning
Collaborative Data Ecosystems
Co-Folding AI

A new operational standard for industrial federation

Delivering a state-of-the-art federated co-folding model across five pharma companies in record time

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